Our lab's goal is to answer the question, “How do axons grow?”. We address this problem by analyzing the biogenesis, transport, and degradation of organelles and cytoskeletal elements in neurons using time-lapse microscopy, mathematical modeling, biophysical analysis, gene disruption, and behavioral studies. Our integrative studies are conducted in both cultured neurons and in vivo in living Drosophila (fruit fly) embryos. Our hope is that a mechanistic understanding of growth cone motility will lead to better treatments for traumatic brain injury, spinal cord injury, stroke, and chronic neurological diseases.

3D reconstruction of a motor neuron in a Drosophila embryo

A 3D reconstruction in a living late stage 16 Drosophila embryo expressing the membrane marker myr-tdTomato in the nervous system driven by the pan-neuronal driver elav-Gal4. This image was aquired by my graduate student Douglas Roossien.

Copyright 2012 Kyle Miller